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Will you live to 120?

The Hundred-and-Twenty Question

Seven chapters on the science of living longer — and how to tell it from the hype. It names and works through the things you actually hear on longevity podcasts: telomeres; the epigenetic “clocks” that claim to read your biological age; the senescent “zombie” cells and the senolytics meant to clear them; the nutrient-and-hunger switches behind fasting, rapamycin, and metformin; the free-radical theory (a beautiful wrong idea) and the antioxidants it inspired; protein aggregation; and cellular reprogramming. For each one it asks the only question that counts: is this a real lever on aging, or just a number someone has learned to move? More mathematical than the rest — the equations are right there on the page, where they earn their keep.

Start reading → PDF EPUB

10chapters
38pages
40kwords

Contents

  1. The Question
  2. The Counting Problem
  3. The Clock and the Lever
  4. The Cells That Won’t Die
  5. The Hunger Switch
  6. The Beautiful Wrong Idea
  7. Folding and Falling Apart
  8. The Reset
  9. The Reckoning
  10. Sources and Further Reading

Interactive notebooks

6 notebooks to work through alongside the chapters. Each one downloads from this site; "open in Colab" runs it in your browser with a free Google sign-in, nothing to install.

  1. Cure vs Slow Aging download .ipynb · open in Colab
  2. Protein Folding Funnel download .ipynb · open in Colab
  3. Senescence Tipping Point download .ipynb · open in Colab
  4. Telomere Weak Biomarker download .ipynb · open in Colab
  5. The Goldilocks Dose download .ipynb · open in Colab
  6. Your Own Epigenetic Clock download .ipynb · open in Colab